R&D Pipeline

Pre-Clinical Publications

Study IDPhaseStudy SubjectsInference
Trier et al. 1Clinical Phase II(36‑month pilot study)

68 myopic children (mean age: 11.3 years)
ND-10 was found to be effective.

Clinical Publications

Study IDPhaseAnimals usedInference
Trier et al. 2Preclinical6 pigmented rabbits (age: 8 weeks)ND-10 was found to be effective.
Cui et al. 3Preclinical7 guinea pigs (age: 3 weeks)ND-10 was found to be effective.
Nie et al. 4Preclinical8 pigmented rabbits (age: 10 days)ND-10 was found to be effective.
Hung et al 5Preclinical16 rhesus monkeys (age: 2-3 weeks)ND-10 was found to be effective.

Summary of preclinical and clinical studies in which ND-10 showed effective results in the treatment of myopia

Our lead program

Theialife’s new molecule is a first in class, novel, oral therapy in the treatment and management of Myopia in children. This first in class molecule will change the Myopia management landscape, especially for children with early-onset Myopia, who otherwise, given the limited therapies available, are bound to progress towards severe and sight threatening Myopia.

ND-10 competitively blocks adenosine receptors. These receptors modulate various retinal neurotransmitters believed to control eye growth. ND 10 increases the collagen concentration and collagen fibril diameter in the posterior sclera and thereby inhibits eye elongation and Myopia progression in animals subjected to form-deprivation or lens induced Myopia.

References

  1. Trier K, Munk Ribel-Madsen S, Cui D, Brøgger Christensen S. Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study. Journal of ocular biology, diseases, and informatics. 2008 Dec;1:85-93.
  2. Trier K, Olsen EB, Kobayashi T, Ribel-Madsen SM. Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, orl-ornithine. British journal of ophthalmology. 1999 Dec 1;83(12):1370-5.
  3. Cui D, Trier K, Zeng J, Wu K, Yu M, Hu J, Chen X, Ge J. Effects of 7‐methylxanthine on the sclera in form deprivation myopia in guinea pigs. Acta ophthalmologica. 2011 Jun;89(4):328-34.
  4. Nie HH, Huo LJ, Yang X, Gao ZY, Zeng JW, Trier K, Cui DM. Effects of 7-methylxanthine on form-deprivation myopia in pigmented rabbits. International journal of ophthalmology. 2012;5(2):133.
  5. Hung LF, Arumugam B, Ostrin L, Patel N, Trier K, Jong M, Smith III EL. The adenosine receptor antagonist, 7-methylxanthine, alters emmetropizing responses in infant macaques. Investigative ophthalmology & visual science. 2018 Jan 1;59(1):472-86.